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KMID : 0043320160390060806
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Archives of Pharmacal Research
2016 Volume.39 No. 6 p.806 ~ p.810
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Induced production of 6,9-dibromoflavasperone, a new radical scavenging naphthopyranone in the marine-mudflat-derived fungus Aspergillus niger
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Leutou Alain Simplice
Yun Keum-Ja
Son Byeng-Wha
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Abstract
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The addition of metal bromides (NaBr and CaBr2) during fermentation of the marine-mudflat-derived fungus Aspergillus niger induced production of a new radical scavenging brominated naphthopyranone, 6,9-dibromoflavasperone (1); and three known naphtho-γ-pyranone monomers, flavasperone (2), TMC-256A1 (3), and fonsecin (4); and one naphtho-γ-pyranone dimer, aurasperone B (5). The structure of 6,9-dibromoflavasperone (1) was assigned through the combination of spectroscopic data analyses and comparison with the spectral data of flavasperone (2). Compounds 1?5 displayed potent radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, with IC50 values of 21, 25, 0.3, 0.02, and 0.01 μM, respectively, and 3?5 were more potent than the positive control, ascorbic acid (IC50, 20.0 μM).
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KEYWORD
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6,9-Dibromoflavasperone, Flavasperone, TMC-256A1, Fonsecin, Aurasperone B, Radical scavenging activity
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